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Higher stress levels increase mast cell activation

Copper and its associated proteins, including ATOX1 and CCS, play notable roles in breast cancer progression, metastasis, and poor clinical outcomes (Huffman and O'Halloran, 2001)

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Moreover, agrin-treated pericytes exhibited elevated levels of ROS and Fe 2+ , along with reduced expression of GPX4 and FTH1, thereby promoting ferroptosis, suppressing pericyte proliferation, and compromising blood-brain barrier function